Central University of Rajasthan, India
Network Management Affiliate
Visceral Leishmaniasis, Vaccine Development
Currently, our laboratory is majorly working on vaccine development against visceral leishmaniasis, a deadly parasitic infectious disease. Till date there is no effective vaccination is available for the treatment of this severe infection. Nevertheless, we are focused on the development of a cost-effective and safe multi-epitope subunit vaccine against this parasitic disease along with drug discovery because the subunit vaccine contains the immunogenic protein which will be potent enough to generate the immunological responses in the host. To achieve our goal, we are utilizing chemical and system biology approaches along with reverse vaccinology approach.
Ojha R, Nandani R, Pandey RK, Prajapati VK*; Emerging Role of Circulating miRNA in the Diagnosis of Human Infectious Diseases. Journal of Cellular Physiology (IF-3.923; Just accepted)
Ojha R, Khatoon N, Prajapati VK*; Conglomeration of Culex quinquefasciatus salivary proteins to devise multi-epitope subunit vaccine against infections caused by blood imbibing transmitter. International Journal of Biological Macromolecules, 2018 June. DOI- 10.1016/j.ijbiomac.2018.06.112. (IF- 3.909)
Ojha R, Nandani R, Chatterjee N, Prajapati VK*; Emerging role of circular RNA as a potential biomarker for the diagnosis of human diseases; Advances in Experimental Medicine and Biology. Publisher- Springer Nature.
Chaterjee N, Ojha R, Khatoon N, Prajapati VK*; Scrutinizing Mycobacterium tuberculosis membrane and secretory proteins to formulate multiepitope subunit vaccine against pulmonary tuberculosis by utilizing Immunoinformatic approaches. International Journal of Biological Macromolecules, 2018 June. 2018 Jun 18;118(Pt A):180-188. (IF- 3.909)
Pandey RK, Ali M, Ojha R, Prajapati VK*; Development of multi-epitope driven subunit vaccine in secretory and membrane proteins of Plasmodium falciparum to convey protection against malaria infection. Vaccine, 2018 Jun 16. pii: S0264-410X(18)30748-5. (IF-3.285)
Khatoon N, Pandey RK, Ojha R, Veeranarayanan SA, Krishnan M Prajapati VK*; Immunoinformatics exploration to design multi-epitope-based subunit vaccine by investigating Leishmania membrane proteins. Journal of Biomolecular Structure and Dynamics; 2018 May; doi.org/10.1080/07391102.2018.1484815 (IF-3.107)
Pandey RK, Sharma D, Ojha R, Bhatt T, Prajapati VK*; Chemical system biology based molecular interactions to identify inhibitors against Q151M mutant of HIV-1 reverse transcriptase. Infection Genetics and Evolution. 2018 May. Doi-10.1016/j.meegid.2018.05.005. (IF-2.545)
Pandey RK, Ojha R, Mishra A, Prajapati VK*; Designing B and T cell multi-epitope-based subunit vaccine against virulence proteins using immunoinformatics approach to control Zika virus infection. Journal of Cellular Biochemistry; 2018 May. DOI: 10.1002/jcb.27110. (IF-2.959)
Pandey RK, Ojha R, Veeranarayanan SA, Krishnan M, Prajapati VK*; Immunoinformatics approaches to design a novel multi-epitope subunit vaccine against HIV infection. Vaccine, 2018 Apr 19;36(17):2262-2272. (IF-3.285)