Amanda Gibson

Post-doctoral Researcher

Aberystwyth, UK

Email: amg39@aber.ac.uk

VALIDATE Role:

Network Associate

Research Keywords:

Tuberculosis, Bovine tuberculosis, host pathogen interaction, innate immunity, macrophage biology

Biography:

Amanda is a Lecturer Innate Immunology at Aberystwyth University. Amanda's research interests lie in underpinning early events required for establishing infection; the interaction between mycobacteria and host cells, particularly with the innate immune system at the point of recognition and uptake and initial responses leading to disease.

Related Websites:

Key Publications:

Tombácz K, Mwangi D, Werling D, Gibson AJ. Comparison of cellular assays for TLR activation and development of a species-specific reporter cell line for cattle. Innate Immun. 2017 May;23(4):329-335. doi: 10.1177/1753425917695445. Epub 2017 Jan 1. PubMed PMID: 28409540.

Gibson AJ, Woodman S, Pennelegion C, Patterson R, Stuart E, Hosker N, Siviter P, Douglas C, Whitehouse J, Wilkinson W, Pegg SA, Villarreal-Ramos B, Werling D. Differential macrophage function in Brown Swiss and Holstein Friesian cattle. Vet Immunol Immunopathol. 2016 Feb 28. pii: S0165-2427(16)30026-5. doi:10.1016/j.vetimm.2016.02.018. [Epub ahead of print] PubMed PMID: 26961672.

Woodman S, Gibson AJ, García AR, Contreras GS, Rossen JW, Werling D, Offord V. Structural characterisation of Toll-like receptor 1 (TLR1) and Toll-like receptor 6 (TLR6) in elephant and harbor seals. Vet Immunol Immunopathol. 2016 Jan;169:10-4. doi: 10.1016/j.vetimm.2015.11.006. Epub 2015 Dec 1. PubMed PMID:26827833.

Conejeros I, Gibson AJ, Werling D, Muñoz-Caro T, Hermosilla C, Taubert A, Burgos RA. Effect of the synthetic Toll-like receptor ligands LPS, Pam3CSK4, HKLM and FSL-1 in the function of bovine polymorphonuclear neutrophils. Dev Comp Immunol. 2015 Oct;52(2):215-25. doi:10.1016/j.dci.2015.05.012. Epub 2015 May 27.PubMed PMID: 26026246.

Patterson NJ, Günther J, Gibson AJ, Offord V, Coffey TJ, Splitter G, Monk I, Seyfert HM, Werling D. Two TIR-like domain containing proteins in a newly emerging zoonotic Staphylococcus aureus strain sequence type 398 are potential virulence factors by impacting on the host innate immune response. Front Microbiol. 2014 Dec 9;5:662. doi: 10.3389/fmicb.2014.00662. eCollection 2014. PubMed PMID: 25538689; PubMed Central PMCID: PMC4260764.

Osvaldova A, Woodman S, Patterson N, Offord V, Mwangi D, Gibson AJ, Matiasovic J, Werling D. Replacement of two aminoacids in the bovine Toll-like receptor 5 TIR domain with their human counterparts partially restores functional response to flagellin. Dev Comp Immunol. 2014 Nov;47(1):90-4. doi: 10.1016/j.dci.2014.07.002. Epub 2014 Jul 11. PubMed PMID: 25020193.