Angelo Izzo
Faculty Member Centenary Institute, Australia Email: a.izzo@centenary.org.au
VALIDATE Role: Network Investigator
Research Keywords: TB Immunopathogenesis, Animal Models, TB Vaccines Immunity
Biography: I am an infectious diseases immunologist, with over 30 years-experience investigating immune responses to pulmonary Mycobacterium tuberculosis infection and tuberculosis vaccines in pre-clinical animal models. My work focuses on identifying critical mechanisms required to develop protective immunity. I have been funded by the US National Institutes of Health for over 20 years to investigate mechanisms of vaccine-induced immunity, and the use of animal models in vaccine development and was the pre-clinical site for testing new tuberculosis vaccines. I am currently investigating the actions of different adjuvant formulations for use in subunit vaccines against tuberculosis. These studies compare adjuvants that activate a diverse array of pathogen recognition receptors in multiple models to determine which can ultimately be used in clinical trials. Another area of investigation in my lab is mycobacterial immunopathogenesis research focusing on understanding the role of co-infections on immunity to M. tuberculosis infection and vaccination.
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