Dr Nastassja Kriel
VALIDATE Role: Associate
Research Key Words: TB, ESX secretion systems, Transcriptional regulation, Persistence, Antibiotic tolerance and resistance.
As a tuberculosis researcher, I am interested in investigating how Mycobacterium tuberculosis enters and maintains a persistent growth state. These viable but non-replicating persister bacteria prevent rapid sterilization due to their antibiotic tolerant phenotype. I am also interested in the specialized ESX secretion systems encoded by mycobacteria and how the secretion of PE and PPE proteins as well as other effector proteins enable intracellular survival of M. tuberculosis.
I completed my PhD at Stellenbosch University, South Africa under the supervision of Professor Rob Warren and I am currently a postdoctoral researcher under the supervision of Samantha Sampson.
Nastassja L. Kriel, Tiaan Heunis, Samantha L. Sampson, Monique J. Williams, Robin M. Warren. Identifying nucleic acid-associated proteins in Mycobacterium smegmatis by mass spectrometry-based proteomics. BMC Molecular and Cell Biology.
James Gallant, Jomien Mouton, Roy Ummels, Corinne ten Haag-Jongman, Nastassja Kriel, Arnab Pain, Rob Warren, Wilbert Bitter, Tiaan Heunis, Samantha Sampson. Identification of gene fusion events in Mycobacterium tuberculosis resulting in novel chimeric proteins. NAR Genomics and Bioinformatics