The VALIDATE Network - Vaccine development for complex intracellular neglected pathogens
Bioinformatician - Postdoctoral Training Fellow
Deadline 14 May 2021
The Francis Crick Institute, Midland Road, London UK
The Francis Crick Institutwe seek a talented and motivated Bioinformatician Postdoctoral Training Fellow (or equivalent) to join Professor Anne O’Garra’s laboratory. The lab works on the regulation of the immune response in infection and inflammatory diseases in experimental models and human cohorts. An overview of the laboratory can be found at: https://www.crick.ac.uk/research/a-z-researchers/researchers-k-o/anne-o’garra/
The successful candidate will join the team lead by Prof A O’Garra at the Francis Crick Institute. The group is interested in studying pathways of protection and pathogenesis in infection and inflammation using bioinformatics analysis and annotation to analyse complex bulk RNA-seq and ATAC-Seq data, as well as Single Cell-RNA-Seq in human disease and mouse models. The candidate will perform such analyses on samples from the airways and blood of cohorts of human tuberculosis (TB) patients and their contacts, a small number of whom only will develop TB. The aim is to establish gene signatures on the early response to Mycobacterium tuberculosis in order to understand the early events in contacts of TB patients who go on to develop TB or not, as compared to those in active TB patients.