VALIDATE Workshop: From Candidate to Vaccine - Translating the Next Generation of Vaccines for Intracellular Pathogens

VALIDATE Translation Workshop

The workshop focused on advancing vaccine candidates for mycobacterial diseases, leishmaniases, and melioidosis, bringing together experts from academia and industry. Held over two days, the event aimed to support VALIDATE members in progressing their vaccine candidates towards viability. It featured a mix of presentations, discussions, and networking opportunities to foster collaboration among researchers and professionals in the field. The workshop brought together experts from academia and industry, aiming to advance current vaccine candidates towards viability.

On the first day, Prof Samantha Sampson opened the session, which featured "Turbo Talks" in which all delegates were given three minutes to introduce themselves and their work. The morning session included insightful talks on tuberculosis, melioidosis, and leishmaniasis vaccine development, with speakers Dr Rhea Coler, Prof Direk Limmathurotsakul and Prof Abhay Satoskar providing comprehensive introductions to the status of vaccine research for each of our focus pathogens. The afternoon focused on first and second-generation vaccines, with Dr Alison Kraigsley discussing next-generation TB vaccines and Dr Claudia Brodskyn addressing immunotherapy in canine visceral leishmaniasis. The day concluded with round-table discussions and a networking dinner at Trader Vic's restaurant don't the banks of the Chao Praya river..

The second day of the workshop opened with a session on third-generation platforms such as mRNA and viral vectors. Dr Steve Reed and Dr Alvaro Borges presented the morning sessions on mRNA vaccines and the tuberculosis vaccine candidate H56. Later, Dr Lisa Morici addressed advances in leishmaniasis and Burkholderia vaccine development. The afternoon explored the challenges of transitioning vaccine candidates to clinical trials, with contributions from Dr Pia Steigler and Prof Siobhan McClean. Throughout the event, delegates engaged in round-table discussions, fostering future collaborations. The workshop successfully provided a platform for exchanging ideas and fostering partnerships to progress vaccine candidates towards clinical application.

 

Agenda

Day One  - 18 July 2024

 


Time Talk Title Speaker
09:00 - 09:05       Welcome Prof Samantha Sampson                                                           
09:05 - 10:35 Turbo Talks - Quick fire talks from all delegates, introducing themselves, their career, their research and vaccine candidates                                                                All delegates

 

Session 1: Introductions
Time Talk Title Speaker
10:35 - 11:00        Break  
11:00 - 11:20 Tuberculosis vaccine development: A comprehensive appraisal of the current state                                                                                                                                 Dr Rhea Coler, University of Washington, USA
11:20 - 11:40 Melioidosis – an update Prof Direk Limmathurotsakul, Mahidol University, Thailand        
11:40 - 12:00 Progress towards development of vaccines for control and elimination of leishmaniasis                                                                                                                                  Prof Abhay Satoskar, Ohio State University, USA
12:00 - 12:15 Q&A  
12:15 - 13:15 Lunch  

 

Session 2: First & Second Generations Vaccines

Time Talk Title Speaker
13:15 - 13:35        Development of vaccines for visceral leishmaniasis in Brazil Prof Myron Christodoulides, University of Southampton, UK
13:35 - 13:55        Immunotherapy with live attenuated Leishmania vaccines to prevent severe disease & reduce transmissibility of infection in asymptomatic canine visceral leishmaniasis Dr Claudia Brodskyn, Fundação Oswaldo Cruz (Fiocruz), Brazil
13:55 - 14:15 Supporting the Next Generation TB Vaccines Dr Alison Kraigsley, Bill & Melinda Gates Foundation, USA
14:15 - 14:30 Q&A  
14:30 - 15:00 Break  
15:00 - 15:20 Safety and Immunogenicity Testing of a Melioidosis Subunit Vaccine Candidate in Non-Human Primates Dr Mary Burtnick, University of Nevada, Reno, USA
15:20 - 15:40 Development and evaluation of attenuated and nanoparticle vaccines against Burkholderia pseudomallei Dr Alfredo Torres, UTMB, USA
15:40 - 15:55 Q&A  
15:55 - 16:40 Round tables  
16:40 - 17:00 Wrap up  
17:00 Day ends  
18:00 - 20:00 Workshop Dinner at Trader Vic's  

 

Day Two  - 19 July 2024

 


Session 3: Third-Generation Platforms (mRNA, viral vectors)
Time Talk Title Speaker
09:00 - 09:10       Welcome back  
09:10 - 09:30 mRNA Vaccines for Global Health                                                                                                                                                                                                                  Dr Steve Reed (RNA), HDT Bio, Seattle, USA                             
09:30 - 09:50 The tuberculosis vaccine candidate H56 Dr Alvaro Borges, Statens Serum Institut, Denmark                  
09:50 - 10:05 Q&A  
10:05 - 10:35 Break  
10:55 - 11:15 Development and Manufacturing of a Burkholderia OMV Dr Lisa Morici, Tulane School of Medicine, USA
11:15 - 11:30 Q&A  
11:30 - 12:30 Round tables  
12:30 - 13:30 Lunch  

 

 

Session 4: Turning Candidates into Vaccines

Time Talk Title Speaker
13:30 - 13:50       Towards sustainable end-to-end mRNA vaccine development and manufacturing for LMIC: An update from the Technology Transfer Hub                                               Dr Pia Steigler, Afrigen (mRNA platform), South Africa                 
13:50 - 14:10 Challenges of progression of a melioidosis vaccine from mice to man: trials, tribulations and tips Prof Siobhan McClean, UCD, Ireland
14:10 - 14:30 Congratulations! It’s a …. Clinical Trial! Mrs Kristin Croucher, Bill & Melinda Gates Foundation, USA
14:30 - 14:50 Q&A  
14:50 - 15:20 Break  
15:20 - 16:30 Final Round table  
16:30 - 17:00 Wrap up  
17:00 Day ends