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Postdoctoral Research Fellow
Australian Institute of Tropical Health and Medicine, James Cook University, Australia
Email: ana.valenciahernandez@jcu.edu.au
VALIDATE Role:
Network Associate
Research Keywords:
Vaccine Development, TB, Animal Models
Biography:
Dr Ana Valencia-Hernandez is an early career researcher with international education and expertise in the fields of immunology, intracellular pathogens, and vaccine development, and possesses a wide-ranging skillset in cellular immunology and microbiology. Trained in several murine infection models, she has gained experience in the design of T cell-based Vaccines for malaria and tuberculosis. Dr Valencia-Hernandez has particular focus on the development of immunisation strategies that promote the generation of tissue resident memory T cells, important for the local control of infections.
Related Websites:
LinkedIn
JCU Research Portfolio
Key Publications:
- Valencia-Hernandez, A. M. Zillinger, T., Ge, Z., Tan, P. S., Cozijnsen, A., McFadden, G., Lahoud, M. H., Caminschi, I., Barchet, W., Heath, W. R., Fernandez-Ruiz, D. (2023). Complexing CpG adjuvants with cationic liposomes enhances vaccine-induced formation of liver TRM cells. Vaccine. https://doi.org/10.1016/j.vaccine.2022.12.047
- Valencia-Hernandez, A. M., Ng, W. Y., Ghazanfari, N., Ghilas, S., de Menezes, M. N., Holz, L.E., Huang, C., English, K., Naung, M., Tan, P. S., Tullett, K. M., Steiner, T. M., Enders, M. H., Beattie, L., Chua, Y. C., Jones, C. M., Cozijnsen, A., Mollard, V., Cai, Y., … Fernandez-Ruiz, D. (2020). A Natural Peptide Antigen within the Plasmodium Ribosomal Protein RPL6 Confers Liver TRM Cell-Mediated Immunity against Malaria in Mice. Cell Host & Microbe, 1–13. https://doi.org/10.1016/j.chom.2020.04.01
- Holz, L. E., Chua, Y. C., de Menezes, M. N., Anderson, R. J., Draper, S. L., Compton, B. J., Chan, S. T. S., Mathew, J., Li, J., Kedzierski, L., Wang, Z., Beattie, L., Enders, M. H., Ghilas, S., May, R., Steiner, T. M., Lange, J., Fernandez-Ruiz, D., Valencia-Hernandez, A. M., … Heath, W. R. (2020). Glycolipid-peptide vaccination induces liver-resident memory CD8+ T cells that protect against rodent malaria. Science Immunology, 5(48), 1–14. https://doi.org/10.1126/sciimmunol.aaz8035
- Masic, A., Valencia-Hernandez, A. M., Hazra, S., Glaser, J., Holzgrabe, U., Hazra, B., & Schurigt, U. (2015). Cinnamic acid bornyl ester derivatives from valeriana wallichii exhibit antileishmanial in vivo activity in leishmania major-infected BALB/c Mice. PLoS ONE, 10(11), 1–20. https://doi.org/10.1371/journal.pone.0142386
Reviews:
- Ghilas, S., Valencia-Hernandez, A. M., Enders, M. H., Heath, W. R., & Fernandez-Ruiz, D. (2020). Resident memory t cells and their role within the liver. International Journal of Molecular Sciences, 21(22), 1–15. https://doi.org/10.3390/ijms21228565
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