Project Team Leader
UK Health Security Agency (UKHSA), United Kingdom (UK)
Email: Alexandra.morrison@ukhsa.gov.uk
VALIDATE Role:
Network Associate
Research Keywords:
TB, Animal Models, Immunology, T-Cells, Gamma Delta T-Cells
Biography:
I am currently working in TB vaccine and drug evaluation at UKHSA. Utilising advanced models of TB, my research primarily utilises time course studies to interrogate the profile and functionality of immune cells in vivo after vaccine and drug regimens and TB disease. My PhD focussed on γδ T cells after the BCG vaccine and associations with health outcomes after TB or COVID-19.
Key Publications:
- Morrison, Alexandra L., et al. "IV BCG Vaccination and Aerosol BCG Revaccination Induce Mycobacteria-Responsive γδ T Cells Associated with Protective Efficacy against M. tb Challenge." Vaccines 11.10 (2023): 1604.
- White, Andrew D., et al. "Influence of aerosol delivered BCG vaccination on immunological and disease parameters following SARS-CoV-2 challenge in rhesus macaques." Frontiers in immunology 12 (2022): 801799.
- Salguero, Francisco J., et al. "Comparison of rhesus and cynomolgus macaques as an infection model for COVID-19." Nature Communications 12.1 (2021): 1260.
- Morrison, Alexandra L., et al. "Cheap and Commonplace: Making the Case for BCG and γδ T Cells in COVID-19." Frontiers in Immunology 12 (2021): 743924.
- White, Andrew D., et al. "MTBVAC vaccination protects rhesus macaques against aerosol challenge with M. tuberculosis and induces immune signatures analogous to those observed in clinical studies." npj Vaccines 6.1 (2021): 4.
