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Principal Researcher and Team leader
Karolinska Institutet, University in Solna, Sweden
Email: Christopher.sundling@ki.se
VALIDATE Role:
Investigator
Research Keywords:
TB, malaria, HIV, B cells, antibodies, adaptive immunity, Innate-adaptive immune regulation
Biography:
Our research focuses on understanding the interplay between different infectious diseases and the immune system. In order to study the immune response after infection, we use state-of-the-art technology to investigate the immune system on a cellular, molecular, and genetic level. We then use bioinformatics to analyse the high-dimensional data and combine the results with clinical variables. By comparing several diseases, we can identify unique features associated with the individual pathogens, which in turn can be useful for developing novel diagnostic tests or pinpoint potential targets for therapeutics. We also achieve an improved understanding of how the immune system responds to a given infection on a systems scale, which we then further investigate mechanistically.
Key Publications:
- Systems analysis shows a role of cytophilic antibodies in shaping innate tolerance to malaria. Lautenbach MJ, Yman V, Silva CS, Kadri N, Broumou I, Chan S, Angenendt S, Sondén K, Plaza DF, Färnert A, Sundling C.Cell Rep. 2022 Apr 19;39(3):110709. doi: 10.1016/j.celrep.2022.110709.PMID: 35443186
- High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids. Silva CS, Sundling C, Folkesson E, Fröberg G, Nobrega C, Canto-Gomes J, Chambers BJ, Lakshmikanth T, Brodin P, Bruchfeld J, Nigou J, Correia-Neves M, Källenius G.Front Immunol. 2021 Nov 23;12:727300. doi: 10.3389/fimmu.2021.727300. eCollection 2021.PMID: 34887849
- Positive selection of IgG+ over IgM+ B cells in the germinal center reaction. Sundling C, Lau AWY, Bourne K, Young C, Laurianto C, Hermes JR, Menzies RJ, Butt D, Kräutler NJ, Zahra D, Suan D, Brink R.Immunity. 2021 May 11;54(5):988-1001.e5. doi: 10.1016/j.immuni.2021.03.013. Epub 2021 Apr 14.PMID: 33857421
- Stabilization of blood for long-term storage can affect antibody-based recognition of cell surface markers. Silva MH, Lepzien R, Ols S, Dahlberg B, Grunewald J, Loré K, Smed-Sörensen A, Correia-Neves M, Empadinhas N, Färnert A, Källenius G, Sundling C.J Immunol Methods. 2020 Jun-Jul;481-482:112792. doi: 10.1016/j.jim.2020.112792. Epub 2020 May 6.PMID: 32387697
- Multiplex analysis of antigen-specific memory B cells in humans using reversed B-cell FluoroSpot. Jahnmatz P, Sundling C, Makower B, Sondén K, Färnert A, Ahlborg N.J Immunol Methods. 2020 Mar;478:112715. doi: 10.1016/j.jim.2019.112715. Epub 2019 Dec 3.PMID: 31809709
- Lipoarabinomannan in Active and Passive Protection Against Tuberculosis. Correia-Neves M, Sundling C, Cooper A, Källenius G.Front Immunol. 2019 Sep 11;10:1968. doi: 10.3389/fimmu.2019.01968. eCollection 2019.PMID: 31572351
- B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets. Sundling C, Rönnberg C, Yman V, Asghar M, Jahnmatz P, Lakshmikanth T, Chen Y, Mikes J, Forsell MN, Sondén K, Achour A, Brodin P, Persson KE, Färnert A.JCI Insight. 2019 Apr 2;5(9):e126492. doi: 10.1172/jci.insight.126492.PMID: 30939125
Weblinks of Interest:
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