Hiro Goto

Hiro Goto

Associate Professor 

Universidade de Sao Paulo (USP), Brazil

Tel: +55-11-3061-7023

Email: hgoto@usp.br





Network Investigator


Research Keywords: 

Leishmaniasis, Immunopathology, Diagnosis, Vaccine



Research areas: immunopathology and diagnosis of leishmaniases. In immunopathology we focus non-specific elements such as lipoprotein fractions, insulin-like growth factor-I in Leishmania infection development, immunopathological mechanisms of lesions in leishmaniasis, susceptibility gene polymorphism in subjects in endemic areas of visceral leishmaniasis and search for potential targets for vaccine candidates. In diagnosis, we develop assays to improve diagnosis of leishmaniases using recombinant Leishmania antigens.


Related Websites: 

CNPq Profile

Google Scholar Profile

ResearcherID Profile


Key Publications:

  • Sato, C.M.; Sanchez, M.C.A.; Celeste, B.J.; Duthie, M.S. ;Guderian, J.; Reed, S.G. ; Brito, M.E.F.; Campos, M.B.; Encarnação, H.V.S.; Guerra, J.; De Mesquita, T.G.R.; Pinheiro,S.K.; Ramasawmy, R.; Silveira, F.T.; Souza, M.A.; Goto, H. Use of recombinant antigens for sensitive serodiagnosis of American tegumentary leishmaniasis caused by different Leishmania species. Journal of Clinical Microbiology 55: 495-503, 2017.
  • De Souza, L.D.; Vendrame, C.M.V.; Jesus, A.R.; Carvalho, M.D.T.; Magalhães, A.S.; Schriefer, A.; Guimarães, L.H.; Carvalho, E.M.; Goto, H. Insulin-like growth factor-I serum levels and their biological effects on Leishmania isolates from different clinical forms of American tegumentary leishmaniasis. Parasites & Vectors, 9: 335, 2016.
  • Real, F.; Florentino, P.T.V.; Reis, L.C.; Ramos-Sanchez, E.M.; Veras, P.S.T.; Goto, H.; Mortara, R.A. Cell-to-cell transfer of Leishmania amazonensis amastigotes is mediated by immunomodulatory LAMP-rich parasitophorous extrusions. Cellular Microbiology 16: 1549-1564, 2014.
  • Vendrame, C.M.V.; Carvalho, M.D.T.; Tempone, A.G.; Goto,H. Insulin-like growth factor-I induces arginase activity in Leishmania amazonensis amastigote-infected macrophages through a cytokine-independent mechanism. Mediators of Inflammation, 2014: 1-13, 2014.
  • Lindoso, J.A.L ; Cota, G. F. ; Da-Cruz, A.M ; Goto, H. ; Maia-Elkhoury, A. N. S. ; Romero, G. A. S. ; Sousa-Gomes, M. L. ;Santos-Oliveira, J.R ; Rabello, A. Visceral Leishmaniasis and HIV Coinfection in Latin America. PLoS Neglected Tropical Diseases (Online), v. 8, p. e3136, 2014.
  • Reis, L.C., Ramos-Sanchez, E.M., Goto, H. The interactions and essential effects of intrinsic insulin-like growth factor-I on growth within macrophages. Parasite Immunology, 35(7-8):239-44, 2013.
  • Cunningham, J.; Hasker, E.; Das, P.; El Safi, S.; Goto, H.; Mondal, D.; Mbuchi, M.; Mukhtar, M.; Rabello, A.; Rijal, S.;Sundar, S.; Wasunna, M ; Adams, E.; Menten, J.; Peeling, R.; Boelaert, M. A global comparative evaluation of commercial immunochromatographic rapid diagnostic tests for visceral leishmaniasis. Clinical Infectious Diseases, 55: 1312-1319, 2012.
  • Goto, H., Lindoso, J.A.L. Current diagnosis and treatment of cutaneous and mucocutaneous leishmaniasis. Expert Review of Anti-Infective Therapy, 8: 419-433, 2010.
  • Vendrame, C. M. V. ; Carvalho, M. D. T. ; Rios, F. J. O. ; Manuli, E. R. ; Petitto-Assis, F.; Goto, H. Effect of insulin-like growth factor-I on Leishmania amazonensis promastigote arginase activation and reciprocal Inhibition of NOS2 pathway in macrophage in vitro. Scandinavian J. Immunol. 66: 287-296, 2007.
  • Goto, H., Gomes, C.M.C., Monteiro H.P., Corbett, C.E.P. & Gidlund, M. Insulin-like growth factor (IGF)-I is a growth promoting factor for Leishmania promastigotes and amastigotes. Proc. Natl. Acad. Sci. (USA) 95: 13211-13216, 1998.