Jayne Sutherland

Associate Professor

MRC Unit, The Gambia

Tel: +220 3170701

Email: jsutherland@mrc.gm

VALIDATE Role:

Network Investigator

Research Keywords:

Clinical trials, protective immunity, TB case-contact cohort, TB-HIV

Biography:

Dr. Sutherland is head of the TB case-contact platform, one of the longest running longitudinal studies on TB cases and their exposed household contacts. Research projects include analysis of protective immunity to Mtb at key transitional points (including protection from infection), development of novel diagnostic tests, analysis of the long-term consequences of TB and analysis of TB-HIV co-infection. The TB Immunology research laboratory provides mechanistic insight and biomarker discovery which underpin all our clinical TB studies. This includes understanding host-pathogen interactions for development of host-directed therapies for TB; defining the role of non-classical T cells, B cells and antibodies in the early response to Mtb infection; defining correlates of risk for progression to active TB; immunity at the site of infection; immune responses to M. africanum (a prevalent strain in West Africa) compared to M. tuberculosis; and immunity to TB in the context of HIV and other co-infections.

Related Websites:

Profile page at MRC The Gambia

Key Publications:

Suliman S*, Thompson E*, Sutherland J et al. Four-gene pan-African blood signature predicts progression to tuberculosis. AJRCCM. 2018. [Epub ahead of print]

Coulter F, Parrish A, Declan Manning D, Kampmann B, Mendy J, Garand M, Lewinsohn DL, Riley EM, Sutherland JS. IL-17 production from Th17, MAIT and γδ cells in tuberculosis infection and disease. Front Immunol. 2017; 8: 1252

Chegou NN, Sutherland JS, Malherbe S, Crampin AC, Corstjens PL, Geluk A, Mayanja-Kizza H, Loxton AG, van der Spuy G, Stanley K, Kotzé LA, van der Vyver M, Rosenkrands I, Kidd M, van Helden PD, Dockrell HM, Ottenhoff TH, Kaufmann SH, Walzl G; AE-TBC consortium. Diagnostic performance of a seven-marker serum protein biosignature for the diagnosis of active TB disease in African primary healthcare clinic attendees with signs and symptoms suggestive of TB. Thorax. 2016; 71: 785-794

Elliott TO, Owolabi O, Donkor S, Kampmann B, Hill PC, Ottenhoff TH, Haks MC, Kaufmann SH, Maertzdorf J, Sutherland JS. Dysregulation of Apoptosis Is a Risk Factor for Tuberculosis Disease Progression. J Infect Dis. 2015; 212: 1469-1479

Coscolla M, Copin R, Sutherland J, Gehre F, de Jong B, Owolabi O, Mbayo G, Giardina F, Ernst JD, Gagneux S. M. tuberculosis T Cell Epitope Analysis Reveals Paucity of Antigenic Variation and Identifies Rare Variable TB Antigens. Cell Host Microbe. 2015; 18: 538-548

Ota MOC, Mendy JF, Donkor S, Togun T, Daramy M, Gomez MP, Chegou NN, Sillah AK, Owolabi O, Kampmann B, Walzl G, Sutherland JS. Rapid diagnosis of tuberculosis using ex vivohost biomarkers in sputum. Eur. Respir. J. 2014; 44: 254-257.

Sutherland JS,Loxton AG, Haks MC, Kassa D, Ambrose L, Lee JS, Ran L, van Baarle D, Maertzdorf J, Howe R, Mayanja-Kizza H, Boom WH, Thiel BA, Crampin AC, Hanekom W, Ota MO, Dockrell H, Walzl G, Kaufmann SH, Ottenhoff TH; GCGH Biomarkers for TB consortium. Differential gene expression of activating Fcγ receptor classifies active TB regardless of HIV status or ethnicity. Clin Microbiol Infect. 2014; 20: O230-8

Wilson H, de Jong BC, Peterson K, Jaye A, Kampmann B, Ota MOC, Sutherland JS. Skewing of the CD4+ T cell pool towards mono-functional antigen-specific responses in patients with immune reconstitution inflammatory syndrome in The Gambia. Clin Infect Dis. 2013; 57: 594-603.

Sutherland JS, Young JM, Peterson KL, Sanneh B, Whittle HC, Rowland-Jones SL, Adegbola RA, Jaye A, Ota MO. Polyfunctional CD4+ and CD8+ T cell responses to tuberculosis antigens in HIV-1-infected patients before and after anti-retroviral treatment. J Immunol. 2010; 184: 6537-6544.