|
Deputy Principal (Research & Enterprise)
St George's University of London (SGUL), UK
Tel: 0044 20 8725 2437
Email: jonfriedland@sgul.ac.uk
VALIDATE Role:
Network Investigator
Research Keywords:
TB, innate immunity, MMPs, migration
Biography:
My main research interests are first, in the innate immune response to tuberculosis and in particular, in the mechanisms regulating control of tissue destruction in patients with a view to developing host directed therapies and secondly, in migrant health. Research is strongly translational from basic cellular mechanisms to investigating patient responses. My team collaborate widely across 5 continents but have a particular long-standing collaboration with partners in Peru.
I am a clinical academic and have recently moved to St. George’s, University of London as Deputy Prinicipal (Research and Enterprise) having spent nearly a quarter of a century at the Hammersmith campus of Imperial College London.
Key Publications:
Price NM, Farrar J, Chau TTH, Mai NTH, Hein TT, Friedland JS “Identification of a matrix-degrading phenotype in human tuberculosis in vitro and in vivo.” J. Immunol. 2001;166: 4223-30.
Moore DAJ, Evans CAW, Gilman RH, Caviedes L, Coronel J, Vivar A, Sanchez E, PiñedoY, Saravia JC, Salazar C, Oberhelman R, Hollm-Delgado M-G, LaChira D, Escombe, Friedland JS. “MODS for Diagnosis of Multidrug Resistant TB in ResourceLimited Settings” N. Engl. J. Med. 2006; 355:1539-50.
Elkington PT, Shiomi T, Breen R, Nuttall RK, Ugarte-Gil CA, Walker NF, Saraiva L, Pedersen B, Mauri F, Lipman L, Edwards DR, Robertson BD, D’Armiento J, Friedland JS. “Matrix metalloproteinase-1 drives immunopathology in human tuberculosis and transgenic mice.” J. Clin. Invest. 2011; 121:182733.
Ong CW, Elkington PT, Brilha S, Ugarte-Gil C, Tome-Estaban MT, Tereza L, Pabisiak PJ, Moores RM, Sathyamoorthy T, Patel V, Gilman RH, Porter JC, Friedland JS. "Neutrophil-derived MMP-8 drives AMPK -dependent matrix destruction in human pulmonary tuberculosis" PLoS Pathogens 2015,10.1371/journal.ppat.1004917
Belton M, Brilha S, Manavaki R, Mauri F, Nijran K, Hong YT, Patel N, Dembek M, Tezera L, Green J, Moores R, Aigbirhio F, Al-Nahhas A, Fryer T, Elkington PT, Friedland JS. "Hypoxia and HIF-1α dependent MMP-1 secretion in human pulmonary tuberculosis” Thorax 2016; 71:1145-53.
Seedat F, Hargreaves S, Nellums LB, Ouyang J, Brown M, Friedland JS. “How effective are screening programmes for migrants in Europe: a systematic review.” The Lancet Infectious Diseases. 2018; S1473-3099(18)30117-8.
Fox K, Kirwan D, Whittington A, Singh S, Krishnan N, Gilman RH, Robertson BD, Porter JC, Friedland JS. “Platelets regulate pulmonary inflammation and tissue destruction in tuberculosis.” Am. J. Respir. Crit. Care Med. 2018; 198(2):245-255.
|
