Khushboo Borah

Khushboo Borah

Postdoctoral Research Fellow

University of Surrey, UK

Email: k.borah@surrey.ac.uk

 

 

 

 

VALIDATE Role:

Network Associate

 

Research Keywords: 

TB, Leprosy, Mycobacterium tuberculosis, Mycobacterium leprae, Host-pathogen metabolic interaction

 

Biography:

I am a postdoctoral research fellow working in the University of Surrey and my research is focused on host-pathogen metabolic interactions and identification of metabolic drug targets in the two major mycobacterial pathogens- Mycobacterium tuberculosis and Mycobacterium leprae. I graduated from the Indian Institute of Technology Guwahati, India in 2013 with engineering degree in Biotechnology. I secured DPhil (PhD) from the University of Oxford in 2018, where my research was directed at understanding carbon metabolism in nitrogen-fixing bacterium using systems biology techniques. I joined University of Surrey in 2016 and in my current research I use metabolomics and mass spectrometry (LC-MS and GC-MS), stable isotope labelling and mass isotopomer analysis and metabolic flux analysis for metabolic profiling of carbon and nitrogen metabolism in intracellular Mycobacterium tuberculosis and Mycobacterium leprae.

 

Key Publications:

 

Borah K , Beyß M, Theorell A, Wu H, Basu P, Mendum T, Nöh K, Beste DJV, McFadden J. 2019. A mixed nitrogen diet and compartmentalized utilization for Mycobacterium tuberculosis replicating in host cells: results of a systems-based analysis. CELL-REPORTS-D-19-00652 (In PRESS). doi: https://doi.org/10.1101/542480

Borah K, Girardi K, Mendum T,  Lery L, Beste DJV, Lara F, Pessolani M, and McFadden J. 2019. Intracellular Mycobacterium leprae utilizes host glucose as a carbon source in Schwann cells. mBio02351-19 (Under revision)

Borah K, Kearney J, Banerjee R, Vats P, Dahale S, Manjari S, Joshi R, Bonde B, Williams D, McFadden J (2019) GSMN-ML-  a  genome  scale  metabolic  network  reconstruction  of  the  obligate  human  pathogen Mycobacterium  leprae. PNTD-D-19-01753. doi: https://doi.org/10.1101/819508

Dias I, Borah K, Amin B, Griffiths H, Sassi K, Lizard G, Iriondo A, Martinez-Lage P (2019). Localisation of oxysterols at the sub-cellular level and in biological fluids. J Steroid Biochem Mol Biol. 2019 Oct;193:105426. doi: 10.1016/j.jsbmb.2019.105426.