Luiz Freitas

Luiz Freitas


Gonçalo Moniz Institute (FIOCRUZ), Brazil

Tel: +55 71 99161 8019






Network Investigator


Research Keywords: 

Visceral leishmaniasis; experimental models of leishmaniasis; granulomatous inflammatory response; liver and spleen tissue response in human and canine visceral leishmaniasis



I study morphological aspects of the immuno-inflammatory response related to resistance and susceptibility (fatal outcome) in liver and spleen of individuals (human and dogs) with visceral leishmaniasis. I am interested in evaluating the effects of vaccines on the hepatic and spleen tissue response, evaluating the morphological pattern of the inflammatory response, the phenotypic profile of the cells and the production of cytokines in situ, as well as the histological organization of the spleen’s white pulp.


Related Websites: 



Key Publications:

SilvaOhare, J ; de Oliveira, I S ; Klevorn, T ; Almeida, V A. ; Oliveira, G G S ; Atta, A M. ; de Freitas, L A R. ; dosSantos, w l. C. . Disruption of Splenic Lymphoid Tissue and Plasmacytosis in Canine Visceral Leishmaniasis: Changes in Homing and Survival of Plasma Cells. Plos One, v. 11, p. e 0156733, 2016.

Lima, I S. ; Silva, J S. ; Almeida, V A. ; Junior, F G. L. ; Souza, P A N. ; Larangeira, D F. ; MouraNeto, J P. ; Fraga, D M. ; dE Freitas, L A. R. ; dosSantos, W L.C. ; Schallig, H D. F. H. . Severe Clinical Presentation of Visceral Leishmaniasis in Naturally Infected Dogs with Disruption of the
Splenic White Pulp. Plos One , v. 9, p. e87742, 2014.

CronembergerAndrade, A ; AragãoFrança, L ; De Araujo, C FI ; Rocha, V J ; BorgesSilva, M C ; Figueiras, C P. ; Oliveira, P R. ; De Freitas, L. A. R. ; Veras, P. S. T. ; PontesdeCarvalho, L . Extracellular Vesicles from LeishmaniaInfected Macrophages Confer an Anti- infection CytokineProduction Profile to Naïve Macrophages. PLoS Neglected Tropical Diseases (Online), v. 8, p. e3161, 2014.

dosSantos, W LC ; Pagliari, C ; Santos, L G ; Almeida, V A ; E Silva, TLV ; Coutinho Jr, J ; Souza, Tulio ; Duarte, M I S ; de Freitas, LAR ; Costa, CHN . A case of conventional treatment failure in visceral leishmaniasis: leukocyte distribution and cytokine expression in splenic compartments. BMC Infectious Diseases (Online) , v. 14, p. 491, 2014.

Rocha, V. P. C. ; Nonato, f. R. ; Guimaraes, e. T. ; Rodrigues de Freitas, L. A. ; Soares, M. B. P. . Activity of antimalarial drugs in vitro and in a murine model of cutaneous leishmaniasis. Journal of Medical Microbiology, v. 62, p. 10011010, 2013.

Petersen, A L O A; Guedes, C E S ; Versoza, C L ; lima, J G B ; Freitas, L. A. R. ; Borges, V M ; Veras, P S T . 17AAG Kills Intracellular Leishmania
amazonensis while Reducing Inflammatory Responses in Infected Macrophages. Plos One , v. 7, p. e49496, 2012

Souza, V L ; Veras, P S T ; WelbyBorges, M ; Silva, T M C ; Leite, B R ; Ferraro, R B ; MeyerFernandes, J R ; Barral, A ; Costa, J M L ; Freitas, L A R de . Immune and inflammatory responses to Leishmania amazonensis isolated from different clinical forms of human leishmaniasis in CBA mice. Memórias do Instituto Oswaldo Cruz (Impresso) , v. 106, p. 2331, 2011.

Rodrigues, C ; Batista, L ; Filho, R ; Santos, C ; Pinheiro, C ; Almeida, T ; Freitas, L ; Veras, P . IFNg expression is upregulated by peripheral blood
mononuclear cells (PBMC) from nonexposed dogs upon Leishmania chagasi promastigote stimulation in vitro. Veterinary Immunology and
Immunopathology , v. 127, p. 382388, 2009.

Santana, C. C. ; Vassallo, J. ; de Freitas,L. A. R. ; Oliveira,G. G. S. ; PontesdeCarvalho, L. C. ; dosSantos, W. L. C. . Inflammation and structural changes of splenic lymphoid tissue in visceral leishmaniasis: A study on naturally infected dogs. Parasite Immunology , v. 30, p. 515524, 2008.

Rodrigues, C. A. T. ; Batista, L F S ; Teixeira, M. C. A. ; Pereira, A. M. ; Santos, P. O. M. ; Oliveira, G G S ; Freitas, L. A. R. ; Veras, P S T . Peripheral blood mononuclear cell supernatants from asymptomatic dogs immunized and experimentally challenged with Leishmania chagasi can stimulate canine macrophages to reduce infection in vitro. Veterinary Parasitology , v. 143, p. 197205, 2007.