Lydia Mosi

Lydia Mosi

Associate Professor

University of Ghana, Ghana

Email: lmosi@ug.edu.gh

 

 

 

 

VALIDATE Role:

Network Investigator

 

Research Keywords: 

Buruli Ulcer, Non-Tuberculous Mycobacteria, Transmission Models

 

Biography:

I am an Associate Professor of Cell and Molecular Biology at the Department of Biochemistry, Cell and Molecular Biology, University of Ghana, and the Deputy Director, Administration, of the West African Centre for Cell Biology of Infectious Pathogens. My PhD in Microbiology is from the University of Tennessee. My research focuses on transmission of Buruli ulcer disease which is caused by Mycobacterium ulcerans, identifying metabolic markers for the development of diagnostic tools and integration of diagnosis and management of neglected tropical skin diseases. My lab is a core member of the World Health Organization Laboratory Network group for SkinNTD diagnosis (SkinNTD-LABNET). I am a fellow of the African Academy of Sciences Affiliates Programme and the African Science Leadership Programme of which I am also a facilitator. I am a recipient of the Mwele Malecela Mentorship (MMM) Program for Women in Neglected Tropical Diseases (NTDs), funded by the World Health Organization.

 

Related Websites: 

 

West African Centre for Cell Biology of Infectious Pathogens

LinkedIn

Twitter

 

Key Publications:

  • Kyei-Baffour ES, Owusu-Boateng K, Isawumi A, Mosi L. Pseudogenomic insights into the evolution of Mycobacterium ulcerans. BMC Genomics. 2024 Jan 22;25(1):87. doi: 10.1186/s12864-024-10001-1. PMID: 38253991; PMCID: PMC10802024.
  • Ayerakwa EA, Abban MK, Isawumi A, Mosi L. Profiling Mycobacterium ulcerans: sporulation, survival strategy and response to environmental factors. Future Sci OA. 2023 Mar 23;9(3):FSO845. doi: 10.2144/fsoa-2022-0044. PMID: 37026027; PMCID: PMC10072065.
  • Kwofie, S. K., Anyimadu, D. T., Aryee, S., Asare, B., Kokroko, N., Owusu, J. A., Afutu, B., Agyapong, O., Mosi, L., Kyei-Baffour, E., Enninful, K. S., Agoni, C., & Wilson, M. D. (2023). BuDb: A curated drug discovery database for Buruli ulcer. J Computational Biophysics and Chemistry, 22(01), 31–41. https://doi.org/10.1142/s273741652350001
  • Gyamfi E, Dogbe MA, Quaye C, Affouda AA, Kyei-Baffour E, Awuku-Asante D, Sarpong-Duah M, Mosi L. Variable Number Tandem Repeat Profiling of Mycobacterium ulcerans Reveals New Genotypes in Buruli Ulcer Endemic Communities in Ghana and Côte d'Ivoire. Front Microbiol. 2022 Jun 23;13:872579. doi: 10.3389/fmicb.2022.872579. PMID: 35814673; PMCID: PMC9262091.
  • Addo SO, Mensah GI, Mosi L, Abrahams AOD, Addo KK. Genetic diversity and drug resistance profiles of Mycobacterium tuberculosis complex isolates from patients with extrapulmonary tuberculosis in Ghana and their associated host immune responses. IJID Reg. 2022 Jun 27;4:75-84. doi: 10.1016/j.ijregi.2022.06.005. PMID: 35813561; PMCID: PMC9263986.
  • TK Tingan, GI Mensah, EB Agyekum, IB Amanor, SO Addo, YI Ayamdoo, M Sarpong Duah, L Mosi, K K Addo. Non-tuberculous mycobacteria, not Mycobacterium bovis, are a significant cause of TB-like lesions observed in slaughtered cattle in Ghana. IJID Reg. 2022. 3, 8-14    .      
  • Kwaffo Y. A., Sarpong-Duah M., Owusu-Boateng K., Gbewonyo W. S., Adjimani J. P., Mosi L. Natural antioxidants attenuate mycolactone toxicity to RAW 264.7 macrophages. (2021) Exp Biol Med (Maywood) 26:15353702211015628. doi: 10.1177/15353702211015628. 
  • Gyamfi E, Narh CA, Quaye C, Abass A, Dzudzor B, Mosi L. Microbiology of secondary infections in Buruli ulcer lesions; implications for therapeutic interventions. (2021). BMC Microbiol. 5;21(1):4. doi: 10.1186/s12866-020-02070-5. 
  • Mosi L., Mutoji N., Basile F. A. , Donnell R., Jackson K. L., Spangenberg T., Kishi Y., Ennis D., and Small P. L.C. (2012) Experimental infection of Medaka (Oryzias latipes) with Mycobacterium ulcerans: A model for transmission, pathogeneses and toxicity to fish. Microb. and infect.; 14(9):719-29. 
  • Mosi L, Williamson H, Wallace JR, Merritt RW, Small PL. (2008). Persistent association of Mycobacterium ulcerans with the West African predaceous insect, Belostomatidae. Appl Environ Microbiol.; 74(22):7036-7042.