TB, systems immunology, innate immunity
I am a clinician scientist and an consultant in Infectious Diseases. I undertook an MRC PhD fellowship to study the role of acute phase responses in anti-bacterial host defence, followed by a Wellcome Trust fellowship on the impact of HIV-1 infection on innate immune hostpathogen interactions in macrophages. This led to the study of HIV-TB co-infection and my current focus on immunological determinants of outcome in tuberculosis. My group combines molecular, cellular and systems level approaches to investigate host-microbial interactions in order to inform novel approaches for diagnosis, patient stratification, and identification of rational targets for therapeutic intervention.
Available at UCL Research Portal