Stellenbosch University, South Africa
TB, drug-susceptibility testing, WGS, novel TB drugs
Nabila Ismail is currently a post-doctoral fellow at the Division of Molecular Biology and Human Genetics at Stellenbosch University. Her research focuses on culture-free or early detection of TB infection and resistance profile information using whole genome sequencing technologies. Nabila achieved all three of her BSc, BSc (Hons) and MSc degrees in Biochemistry cum laudefrom the University of Pretoria. Following this, she worked as a research assistant at the NICD Centre for Tuberculosis (a WHO supranational laboratory) where she was actively involved in whole genome sequencing of isolates received from the National Drug Resistance Survey. During this time, she also assisted with the standardization of bedaquiline MIC testing on solid media. She then pursued her PhD in Medical Microbiology through the University of Pretoria and in association with the NICD Centre for Tuberculosis. Her doctoral thesis focused on identifying the optimal method for generation of in vitro mutants to novel and repurposed drugs and she successfully created a number of bedaquiline-, clofazimine- and linezolid-resistant mutants to uncover the genetic basis of resistance. All of the mutants were subjected to whole genome sequencing analysis and phenotypic screening. She published four articles during the course of her PhD.
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