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Assistant Professor
Department of Microbiology, Immunology and Infectious Diseases, University of Calgary
Email: Nargis.khan1@ucalgary.ca
Tel: +1-587-966-9576
VALIDATE Role: Network Associate
Research area eywords: Mtb, Tuberculosis, Innate Immunity, Vaccine development, Aging
Biography
Dr. Nargis Khan completed her PhD at IMTECH-Jawaharlal Nehru University, New Delhi, India. She worked as a postdoctoral fellow with Dr. Maziar Divangahi at Meakins-Christie Laboratories at MUHC, McGill University. Her PDF research study at McGill is focused on three conceptual frameworks of immunity to TB: Host Resistance, Disease tolerance and Trained immunity. Through her PDF program, she has been a proliferative investigator with outstanding publications in Cell, Science Immunology, Mucosal Immunology. She received numerous awards, including FRQS and CIHR. She recently started as an Assistant Professor at the University of Calgary.
Key publications
- M. tuberculosis reprograms hematopoietic stem cells to limit myelopoiesis and impair trained Immunity. Khan N, Downey J, Sanz J, Blankenhaus B, Kaufmann E, Pacis A, Pernet E, Ahmed E, Nijnik A, Mazer B, Sassetti C, Soares MP, Barreiro L, Divangahi M. Cell, 2020
- Intestinal dysbiosis compromises alveolar macrophage immunity to Mycobacterium tuberculosis. Khan N, Mendonca L, Dhariwal A, Fontes G, Menzies D, Xia J, Divangahi M, King IL, Mucosal Immunology, 2019
- BCG educates hematopoietic stem cells to generate protective innate immunity against tuberculosis. Kaufmann E, Sanz J, Dunn JL, Khan N, Mendonça LE, Pacis A, Tzelepis F, Pernet E, Dumaine A, Grenier JC, Mailhot-Léonard F, Ahmed E, Belle J, Besla R, Mazer B, King IL, Nijnik A, Robbins CS, Barreiro LB, Divangahi M. Cell, 2018
- Mitochondrial cyclophilin-d regulates T cell metabolic responses and host tolerance to tuberculosis. Tzelepis F*, Blagih J*, Khan N*, Gillard J, Mendonca L, Joubert P, Jones R, Divangahi M * Equal Contribution. Science Immunology, 2018
- Bcl-xL mediates RIPK3-dependent necrosis in M. tuberculosis-infected macrophage. Zhao X*, Khan N*, Tzelepis F, Nishimura T, Gan H, Park S, Divangahi M, Remold H. *Equal Contribution. Mucosal Immunology, 2017
- Altered gut microbiota promotes the survival of M tuberculosis. Khan N, Vidyarthi A, Nadeem S, Negi S, Nair G, Agrewala JN. Frontiers Immunology, 2016
Weblinks of interest
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