Imperial College London, UK
TB, Animal models, Macrophage models, Fluorescence
My primary work focuses on developing and analysing tools for TB vaccine testing in a human challenge model. I am also involved in investigating the effectiveness of antimicrobial peptides and drug based delivery systems to improve TB treatment. I have a keen interest in human challenge models, innate immune responses to infection and new advances in treatment and diagnosis of TB.
Arnett E, Krishnan N, Roberstons BD, Schlesinger LS. (2016). Host Pathogen Biology for Airborne Mycobacterium tuberculosis: Cellular and Molecular Events in the Lung. In Drug Delivery Systems for Tuberculosis Prevention and Treatment (pp. 11-47)
Krishnan N, Robertson BD, Thwaites GE. 2013. Pathways of IL-1β secretion by macrophages infected with clinical Mycobacterium tuberculosis strains. Tuberculosis. 93(5):538-547.
Krishnan N, Malaga W, Constant P, Caws M, Chau TTH, Salmons J, Lan NTN, Bang ND, Daffé M, Young DB, Robertson BD, Guilhot C, Thwaites GE. 2011. Mycobacterium tuberculosis Lineage Influences Innate Immune Response and Virulence and Is Associated with Distinct Cell Envelope Lipid Profiles. PLoS One. 6(9):e23870.