Sarah Sebastian

Sarah Sebastian

Director of Virology

Vaccitech Ltd, UK

Tel: 01865 808818






Network Associate


Research Keywords: 

Viral vectored vaccines, cellular immune response



Sarah Sebastian is Director of Virology at Vaccitech Ltd, a spin-out company from the Jenner Institute at the University of Oxford focussing on clinical development of viral vectors as a leading T-cell inducing vaccine platform. Sarah has more than 15 years’ experience in virology, parasitology and vaccinology. She obtained a PhD from Columbia University, New York, on the topic of retrovirus restriction by cellular proteins, and also holds an MSc in Control of Infectious Diseases from the London School of Hygiene and Tropical Medicine. As a postdoctoral Marie Curie fellow at Imperial College London, she investigated molecular signalling pathways of the malaria parasite. Prior to joining Vaccitech in January 2018, she was a senior scientist at the Jenner Institute at the University of Oxford, where she worked on genetic engineering of viral vaccine vectors with the aim to improve vaccine immunogenicity.


Related Websites: 

Vaccitech website


Key Publications:

Halbroth BR, Sebastian S, Poyntz HC, Bregu M, Cottingham MG, Hill AVS, Spencer AJ. Development of a Molecular Adjuvant to Enhance Antigen-Specific CD8+ T Cell Responses. Sci Rep. 2018 Oct 9;8(1):15020

Sebastian S, Lambe T. Clinical Advances in Viral-Vectored Influenza Vaccines. Vaccines (Basel). 2018 May 24;6(2). pii: E29.

Humphreys IR, Sebastian S. Novel viral vectors in infectious diseases. Immunology. 2018 Jan;153(1):1-9.

Ewer K, Sebastian S, Spencer AJ, Gilbert S, Hill AVS, Lambe T. Chimpanzee adenoviral vectors as vaccines for outbreak pathogens. Hum Vaccin Immunother. 2017 Dec 2;13(12):3020-3032.

Sebastian S, Pavot V, Turner AV, Matthews J, Gilbert SC. Generation and Production of Modified Vaccinia Virus Ankara (MVA) as a Vaccine Vector. Methods Mol Biol. 2017;1581:97-119.

Morris SJ, Sebastian S, Spencer AJ, Gilbert SC. Simian adenoviruses as vaccine vectors. Future Virol. 2016 Sep;11(9):649-659.

Sebastian S, Gilbert SC. Recombinant modified vaccinia virus Ankara-based malaria vaccines. Expert Rev Vaccines. 2016;15(1):91-103.

Sebastian S, Brochet M, Collins MO, Schwach F, Jones ML, Goulding D, Rayner JC, Choudhary JS, Billker O. A Plasmodium calcium-dependent protein kinase controls zygote development and transmission by translationally activating repressed mRNAs. Cell Host Microbe. 2012 Jul 19;12(1):9-19.

Berthoux L, Sebastian S, Sokolskaja E, Luban J. Cyclophilin A is required for TRIM5{alpha}-mediated resistance to HIV-1 in Old World monkey cells. Proc Natl Acad Sci U S A. 2005 Oct 11;102(41):14849-53.

Sebastian S, Luban J. TRIM5alpha selectively binds a restriction-sensitive retroviral capsid. Retrovirology. 2005 Jun 20;2:40.