National Institutes of Biomedical Innovation, Health and Nutrition (NIBIOHN), Japan
TB, animal models,vaccine
Professor Yasuhiro Yasutomi received his DVM degrees from Rakunogakuen Univesity, Hokkaido, Japan and his Ph.D. from the Graduate School of Veterinary Medicine, Rakunogakuen University from 1986-1990. He was a Research fellow (Immunology) at Harvard Medical School from 1990-1991 and then Instructor 1992-1994. He was Instructor in Medicine at Department of Viral Pathogenesis in Beth Israel Hospital in Harvard Medical School from 1994-1996. He was associate professor in Mie University Graduate School of Medicine from 1996-2007. He is Director at Tsukuba Primate Research Center in National Institutes of Biomedical Innovation, Health and Nutrition, and Professor in Mie University Graduate School of Medicine in July 2007 to present. He is an immunologist in vaccine development field.
Laboratory of Immunoregulation and Vaccine Research webpage
Mizuno S, Yasutomi Y. et al., SOCS1 antagonist-expressing recombinant BCG enhances antituberculosis protection in a mouse model, J.Immunol 2019, 203;188-197.
Bu W, Yasutomi Y, Nabel GJ, Kanekiyo M, Cohen JI, et al., Immunization with components of the viral fusion apparatus elicits antibodies that neutralize Epstein-Barr virus in B cells and epithelial cells. Immunity2019, 50:1305-1316.
Sanada T, Yasutomi Y, Kohara M. et al., Avian H5N1 influenza virus infection causes severe pneumonia in the Northern tree shrew (Tupaia belangeri).Virology. 2019,529:101-110.
Yamamoto T, Yasutomi Y, Ishii KJ. et al., A unique nanoparticulate TLR9 agonist enables a HA split vaccine to confer FcγR-mediated protection against heterologous lethal influenza virus infection. Int Immunol. 2019, 31:81-90.
Takeuchi S, Yasutomi Y, et al., Elevated Membrane Cholesterol Disrupts Lysosomal Degradation to Induce β-Amyloid Accumulation: The Potential Mechanism Underlying Augmentation of β-Amyloid Pathology by Type 2 Diabetes Mellitus.Am J Pathol. 2019, 1892:391-404.
Yamamoto T., Yasutomi Y. et al., STING agonists activate latently infected cells and enhance SIVspecific responses ex vivo in naturally SIV controlled cynomolgus macaques Sci Rep 2019,9(1):5917.
Ageyama,N., Yasutomi,Y., et al., Successful Inflammation Imaging of Non-Human Primate Hearts Using an Antibody Specific for Tenascin-C. Int Heart J 2019.60:151-158.
Nakatake M., Yasutomi Y., Nakamura T. et al., Partial Deletion of Glycoprotein B5R Enhances Vaccinia Virus Neutralization Escape while Preserving Oncolytic Function. Mol Ther Oncolytics 2019, 14:159-171.
Soma S, Yasutomi Y. et al., Primary role of suppressor of cytokine signaling 1 in Mycobacterium bovis BCG infection. Infection and Immunity 2018,30:471-480.
Nagatake T, Yasutomi Y, Kunisawa J. et al., Immunological association of inducible bronchusassociated lymphoid tissue organogenesis in Ag85B-rHPIV2 vaccine-induced anti-tuberculosis mucosal immune responses in mice. Int Immunol 2018,30(10):471-481.